Most artificial cannabinoids are agonists with the cannabinoid receptors. They are already designed to be comparable to THC,[9] the pure cannabinoid Together with the strongest binding affinity for the CB1 receptor, and that is linked to the psychoactive effects or "high" of cannabis.[10] These synthetic analogs often have greater binding affinity and larger potency on the CB1 receptors.

Inside the early 2000s, synthetic cannabinoids began for use for leisure drug use in an make an effort to get equivalent outcomes to cannabis. Due to the fact artificial cannabinoid molecular buildings vary from THC together with other illegal cannabinoids, artificial cannabinoids weren't technically illegal. Considering the fact that the invention of the use of artificial cannabinoids for leisure use in 2008, some artificial cannabinoids are actually produced illegal, but new analogs are regularly synthesized to stay away from the restrictions.

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